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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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  • Cancer Prevention and Treatment:: Cialis can reduce the risk of developing invasive breast cancer by slightly increasing blood pressure. However, Cialis can increase the risk of fainting or experiencing dizziness when standing. If you find that this interaction becomes necessary, seek medical advice.
  • Grapefruit and Grapefruit Juice:

    Cialis (tadalafil) can enhance the blood pressure-lowering effects of the medications, which may increase your risk of side effects like dizziness or dizziness upon taking the medication.

    Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

    You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

    There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

    • Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

    • Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

    for chest pain or use Rectogesic ointment?

    • Nicorandil (Ikorel), used to treat angina

    • Cimetidine, used to treat stomach or duodenal (peptic) ulcers

    • Theophylline, used to treat asthma

    • Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

    • Anti-fungals such as itraconazole and ketoconazole

    • Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

    • Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

    • Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

    • Recreational drugs:- amyl nitrate (poppers)

    If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

    Read available consultation questionnaire information online for “Tadalafil interactions with other medicines”

    Do not take Tadalafil if you are currently taking any other medicine which can cause your health condition to be worse or you are taking any other medicines. Medicines can be taken together, or even two people. If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that your doctor should know?” section on the medical questionnaire. Then, our doctor will have a case of emesis without taking any medication.

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    may affect the heart and can cause symptoms such as palpitations, tachycardia, tachypneic, shortness of breath, incoordination, tachypneic, meibered circulation, tingly feeling, numbness, tingling, weakness, confusion, dizziness, and blurred vision.

    Symptoms of tachypneic can increase after taking Tadalafil and may be sudden and severe (e.g. with passing of the time). If you have emmumatisms and have a history of cardiovascular diseases, then Tadalafil may affect your clinical condition.

    Tadalafil should be taken at the lowest dose and with no other medicines to reduce the risk of its effects.

    There are several medicines that can be taken with Tadalafil to improve your response.

    - macrolide antibiotics:- erythromycin, clarithromycin,nalidixic acid, and azithromycin

    - iron - iron supplements, or - erythromycin

    Tadalafil may be taken with or without food.

    Tadalafil may take 2 to 15 days to start working in your body, with Cialis and Estradiol being the longer-lasting effects. You may need to take Tadalafil for as long as your clinical condition continues after taking the tadalafil, the longer you take Tadalafil.

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    Cialis is an oral prescription medication that is used to treat erectile dysfunction (ED) in men. It contains tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, which works by relaxing the muscles in the walls of blood vessels. This helps to improve blood flow to particular areas of the body. It can also improve erectile function by helping to relax the penis and improve blood flow to the penis when sexually stimulated.

    Cialis is available as a generic product which is usually sold in pharmacies. It is also available in several other countries, including the USA, Europe, and Australia.

    Cialis comes in various strengths and forms, including:

    • 20mg
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    Cialis works by helping to increase blood flow to the penis. This helps to achieve and maintain an erection.

    It can be taken before, during, or up to 30 minutes after a sexual activity. It is important to avoid consuming grapefruit juice while taking Cialis, as it can affect the absorption of the drug.

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    Objectives:To investigate the efficacy of sildenafil (Viagra) treatment in men with erectile dysfunction (ED) in the community setting and to provide an overview of the current evidence regarding treatment efficacy of sildenafil (Viagra).

    Methods:The study was a single-center, double-blind, placebo-controlled, randomized, fixed-dose, crossover, fixed-dose crossover study of treatment with sildenafil (Viagra) and tadalafil (Cialis). Sildenafil was administered as a single dose or in combination with tadalafil, while the other drugs were administered as a single dose or in combination with sildenafil.

    Results:Efficacy was assessed using International Index of Erectile Function (IIEF) domain score and Global Assessment Questionnaire (GAQ) domain score. Sildenafil was significantly more effective than tadalafil in the treatment group compared with the placebo group (n = 9) at 5 days, and at 6 weeks, compared with the treatment group (n = 8). The results showed that the treatment group experienced a significantly greater improvement in the GAQ domain score at 5 days, compared with the treatment group at 4 weeks (n = 8). Sildenafil was also significantly more effective in the treatment group than in the placebo group at 5 days, and at 6 weeks, compared with the treatment group at 4 weeks (n = 8). The GAQ score was also significantly improved at 5 days, compared with the treatment group at 4 weeks (n = 8). The mean difference was significant at 5 days (n = 8) and 6 weeks (n = 8).

    Conclusions:The study demonstrated that sildenafil and tadalafil significantly improved the GAQ domain score and compared with the treatment group at 5 days, and 6 weeks.

    A study of the efficacy of sildenafil (Viagra) treatment in men with erectile dysfunction (ED) in the community setting. (Department of Clinical Medicine, Toronto, Canada)

    P

    Sildenafil is the first oral phosphodiesterase type 5 inhibitor approved for the treatment of erectile dysfunction in men with erectile dysfunction, and is an oral therapy for ED. Sildenafil has been shown to be effective in the treatment of ED by improving erectile function. However, sildenafil is not an appropriate first-line treatment for ED, particularly for men with a history of organic cardiovascular disease. Sildenafil is only FDA approved for the treatment of ED in the United States. We conducted a pilot study of the efficacy of sildenafil in a community setting and assessed the safety and tolerability of the drug in men with ED. A single-arm, placebo-controlled, double-blind study was conducted in men with ED in the community of Toronto, Canada. The primary study objective was to determine whether the treatment group demonstrated a significant improvement in sexual function compared with the control group.

    Sildenafil is a selective, reversible inhibitor of the enzyme phosphodiesterase type 5 (PDE5). Sildenafil is a specific, short-acting oral medication that is rapidly absorbed from the gastrointestinal tract. Approximately 50 to 100 times daily sildenafil was absorbed from the gastrointestinal tract when given alone or in combination with tadalafil or sildenafil at dosages of up to 100 times the recommended starting dose for the treatment of erectile dysfunction. The dose of sildenafil was increased up to 100 times per day to achieve maximum effective plasma levels of up to 100 times that of the recommended starting dose. Sildenafil was given as a single dose or in combination with tadalafil or sildenafil at dosages of up to 100 times the recommended starting dose for the treatment of erectile dysfunction. Sildenafil was administered as a single dose or in combination with tadalafil or sildenafil at dosages of up to 100 times the recommended starting dose for the treatment of erectile dysfunction.